Looking for things to do with my newly acquired benzaldehyde, in the rhodium achieve there was found a synth for phenyl2nitropropene p2np going like this. Phenyl2nitropropene literature syntheses nbutylamine catalysis in ethanol solvent 1. In retrospect, i dont think that my method is good for large scale productions chemically and economically speaking. Reagents utilized for the nitrostyrene synthesis to p2p included nitroethane, benzaldehyde, iron powder, and iron iii chloride all from sigmaaldrich chemical co. If you want to make a few 100 g of amphetamines, you d better convert the phenyl2nitropropene into phenylacetone. Can say that the p2p approach is much simpler, much easier workup. Between the 3rd and 4th addition about 20% to 25% of. It is a synthesized chemical, unlike cocaine which is derived from a plant. Veniero gambaro, determination of 1phenyl2propanone p2p by hsgcms in a. I found a tutorial on amphetamine synthesis about a week ago, and currently it can only be accessed via inspect element tricks and caching because the guy who runs the website hasnt renewed his registration for it. He used 15 ml benzaldehyde, 11 ml nitroethane and 3 gr ammonium acetate. The synthesis and investigation of impurities found in. This is a legal question, but perhaps you guys could help.
It is a colorless liquid with a characteristic almondlike odor. Also, kind of confused about what is produced from this. We have suggested a mechanism for the formation of 1chloro p2p, where the enol form of p2p attacks a positive chloride ion in solution. It says after 6 hours of heating an oil will form, which on cooling overnight gives yellow crystals.
Nitroethane is an organic compound having the chemical formula c 2 h 5 no 2. Largescale methamphetamine manufacture from p2p erowid. If you replace ethylamine with nitroethane, then the reaction would work via the henry reaction. This is everything you need for making p2np, from left to right.
A good way to convert benzaldehyde into p2p without isolating the p2np is outlined in patent us2557051 1951. It can be produced by the reaction of benzaldehyde and nitroethane in the. Bakers yeast saccharomyces cerevesiae is used in the fermentation. Nitroethane is typically harder to obtain than benzaldehyde. The manufacture of p2p utilizing benzaldehyde and nitroethane is described. Benzaldehyde can be derived from natural sources and is widely used by the chemical industry in the preparation of various aniline dyes, perfumes, flavorings, and pharmaceuticals.
Methamphetamine, also referred to as meth, is a psychostimulant that belongs to amphetamine and phenethylamine class of psychoactive drugs. This reaction was incomplete, less p2p was detected by nmr and there was also a new impurity formed, which was identified as 1chloro1phenyl2propanone 1chloro p2p 15 in 21% yield from 1 h nmr. Anyway, perfoming the benzaldehyde nitroethane condensation with butylamine in toluene and then reducing the nitropropene to p2p by adding water and iron to the henrycondensation postrxn mixture and dripping hcl into it, steam distill, separate and, voila. Usually, its reacted with nitroethane in the henry reaction to produce phenyl2nitropropene p2np. The guy from once bought l drums of benzaldehyde, nitroethane and dmso. P2p is reductively aminated with alhg and nitromethane to give meth then swim also found this. Nitrostyrenes are typically made using some variant of the henry reaction. Im planning on reacting it with sodium ethyl sulfate. Condensation of benzaldehyde with nitroethane yields lphenyl2nitropropene. You obviously dont know that nitrostyrene is a class of chemical, not just a single chemical thats easy to buy or make. Synthesis of phenyl2propanone from benzyl chloride 79 mmol and acetic anhydride 686 mmol by electrolysis of the reaction mixture. Havent found any nitroethane yet but it will be no problem for raf.
Under strong stirring, a methanolic koh solution same molar amount as the benzaldehyde, plus a bit of excess is added dropwise over the course of one hour. One can establish secure communications using pgp encryption software and anonymous. Rather than connecting to the internet, p2p software allows surfers to connect with. This can be turned into either amphetamine or phenylacetone p2p relatively easily. It is the simplest aromatic aldehyde and one of the most industrially useful. The anode is made of magnesium or aluminium, the cathode of nickel, the solvent is dmf 110g and the supporting electrolyte is tetrabutylammonium fluoroborate 2. When the contents were cooled and stirred a heavy, yellow, crystalline mass formed immediately. P2np microwave crystallization problem swim recently did the p2np synthesis using ammonium acetate as a catalyst and microwave heating. The benzaldehyde and a slight excess of nitromethane are dissolved in methanol and cooled with a salt ice bath. Stimulants amphetamine from benzaldehydenitroethane. A drug precursor is a substance which can be used to make illicit drugs. Anyone know if this could cause problems in a nitroethane synth. The lists are designated within the controlled substances act but can be modified by the u. Acetaldehyde 50% in water is used as hydrogen acceptor in a ratio of 1 to 1 to benzaldehyde.
The ratio s you should use are 1mol benzaldehyde and 1 mol nitroethane and 0,1mol rnh2. Determination of 1phenyl2propanone p2p by hsgcms in a. It also maintains list i of chemicals and list ii of chemicals, which contain chemicals that are used to manufacture the controlled substancesillicit drugs. I am going to try to prepare some p2np from benzaldehyde and nitroethane following this procedure. The anode is made of magnesium or aluminium, the cathode of nickel, the solvent is dmf 110g and the supporting electrolyte is tetrabutylammonium fluoroborate 2 g, 6 mmol. Phenyl2nitropropene is added to a refluxing mix of glacial acetic acid, and iron powder. Benzaldehyde c 6 h 5 cho is an organic compound consisting of a benzene ring with a formyl substituent. Also, the nitrostyrene thats used to make p2p is called phenyl2nitropropene and is made by reacting benzaldehyde with nitroethane. For meth, or nethylamphetamine which is rather nice, smoother than meth, not as weightpotent but the rough edges have been filed off, and its more potent than straight up phet, amalgam reductions with methylamine or ethylamine, or nitromethane or nitroethane respectively are usually used these require hazardous mercuric hgii salts. Pure nitroethane is colorless and has a fruity odor. Similar in many regards to nitromethane, nitroethane is an oily liquid at standard temperature and pressure.
This rulemaking finalizes a september 25, 2000 notice of proposed rulemaking 65 fr 57577 in which dea proposed the addition of red phosphorus, white phosphorus also known as yellow phosphorus and hypophosphorous acid and. Finally, results are presented for samples of benzaldehyde, 1phenyl2nitropropene and amphetamine that had been seized at a clandestine amphetamine laboratory. He heated it the same way as described above, but 6 times instead of 4. Benzaldehyde is an aromatic aldehyde bearing a single formyl group with an almond odor. I am trying to synthesize p2np for an experiment im documenting online, and i have a hard time. Benzaldehyde will be converted to p2np with cyclohexylamine. Reductive amination of p2p using platinum dioxide catalyst. Examples of such precursors and drugs made with them are listed below.
I read a post on the vespiary about this and it seemed like an. Manufacture of 1 phenyl2propanone using benzaldehyde and nitroethane. Its the result of the reaction between two controlled precursors benzaldehyde and nitroethane, so i would guess its illegalcontrolledwatched, but its not on the deas list. We will be using a twostage procedure involving the cope modification of the knoevengel reaction and an ironacid reduction procedure. The reaction mixture is brought over into a beaker and cooled in the fridge 4c. Condense benzaldehyde and nitroethane to yield phenyl2nitropropene. Amino alcohol via akabori, trial run sciencemadness. High yeilding isosafrole to mdp2np pseudonitrosite proceedure by antibody2 022001. The resulting solution was refluxed for two hours and then poured into icewater. Structurally, meth is similar to amphetamine and methcathinone. Orbitals are for mathematicians organic chemistry is for people who likes to cook.
Set a 1l rbffbf into an oil bath and add ingredients benzaldehyde w nitroethane and. The united states drug enforcement administration dea maintains lists regarding the classification of illicit drugs see dea schedules. At one point he offered a whole drum, think of dmso or benzaldehyde, at ebay. Benzal and acetaldehydew are added in four portions of 0,2% of the volume of the fermentation broth over a time of 7 to 8 hours. The process is known as the knoevenagelwalter condensation which can turn a substituted benzaldehyde such as piperonal x or plain old benzaldehyde speed into an intermediate called a pnitropropene. Trying out a small scale synthesis of nitroethane in my new 1019 glassware the synthesis is published as being from gerard desseigne and henri giral.
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